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Kuboyama T, Tohda C, Komatsu K

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A study examining early-weaned mice (at the age of 14 days) and intraperitoneally inoculated with BCG (Mycobacterium bovis cepa Moreau) reported that glutamine supplementation increased leukocytes, lymphocytes, and neutrophils in the peripheral blood, while BCG inoculation reduced the percentage of lymphocyte and increased the count and percentage of neutrophils

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Hence, this review details how nanomedicines overcome these limitations through active targeting, enhanced tumor accumulation, stimuli-responsive drug release, and co-delivering multiple drugs for combination therapy

however, the authors did not compare the improvements with the placebo group