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And my diabetes med also induces the same CYP3A4 enzyme

While the peak for GSH (2.98 min) gradually decreased, the signal corresponding to GSSG increased (4.37 min), indicative of the expected chemical transformation (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] Jerome MS, Kuthethur R, Kabekkodu SP, Chakrabarty S

Moreover, Con A-injected mice also showed low GSH/GSSG ratio, increased hydrogen peroxide and high MDA level in the liver and spleen compared with Con A-injected WT mice (Figure 6)

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Several mechanisms contribute to therapy resistance such as xenobiotic-metabolism, drug efflux, and apoptosis evasion, among several others [6]