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This mechanism lets sirtuins take part in many body processes

Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

It does this by neutralizing free radicals and reducing oxidative stress

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A retrospective off-label chart review study reported that treatment with belimumab led to significantly lower epidermal growth factor (EGF) concentrations [46], although the role of EGF in the pathogenesis or development of pSS remains elusive