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Notably, Cys119 and Cys162 have been identified as the principal sites for oxidation and significantly influence the regulatory dynamics of MKK3

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It is important to note that pyroptosome is not necessary for the execution of pyroptosis, which can occur by NLRC4 dependent Caspase-1 activation [92]

It is well-established fact that the physiological function of the host is altered by high intracellular ROS concentration which weakens the host immune system and becomes more prone to parasitic diseases [39]

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These discordant findings may reflect the much lower activity of GFAT in freshly isolated compared to cultured ECs, which may be insufficient to compromise NADPH levels [68]