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p62 directly interacts with Keap1 and competitively inhibits the Keap1-Nrf2 interaction, which stabilizes Nrf2 and promotes its accumulation in the nucleus

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We emphasize lessons from earlier approaches that are still relevant today as well as emerging strategies such as integrated venomics and peptide-display libraries that create new avenues for peptide drug discovery

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Blood 110(11):788a, 2007

Although tofacitinib is a specific JAK1/JAK3 inhibitor, it can be begun in patients who are not already using it and be continued in those using it during a pandemic (Jacobs et al., 2020)