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An SD diet exacerbates weight loss, reduces colon length, and increases stool bleeding and diarrhea in models of DSS-induced colitis and in shPsat1 mice (short hairpin RNAs, shRNAs targeting the 2nd gene in the SSP pathway), consistent with worsened disease severity and inflammation 62,114

Conversely, the prospective influence of a target or outcome measure within a model (together with its constraints) must be conveyed to those implementing it in clinical trials

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