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In this scenario, the isoelectric point is the arithmetic mean of these two pKa values, calculated by the formula: pI = (pKa1 + pKa2) / 2

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These effects occur through inhibition of NF-kappaB nuclear translocation and suppression of MAPK signaling pathway activation, reducing transcription of inflammatory mediator genes

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Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose