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INTRODUCTION In the first two parts of this series, we focused on the basic immunobiology of severe COVID-19 disease and the role of inflammatory cytokines in driving respiratory damage, coagulopathy, end-organ failure, and death, which is idealized in Figure 1

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Drug eruptions, like many other inflammatory diseases, are often associated with an infiltrate of eosinophils and/or neutrophils Patch tests can be used to help confirm allergy to carbamazepine Management Stop the offending drug if possible Supportive therapy eg emollients and topical steroids if needed Cross-reactivity 10% of patients allergic to penicillin have cephalosporin allergy Patients allergic to one sulphonamide antibiotic should avoid other antibiotics in the same group

Rates of statin use tended to be lower in ALT responders than in non-responders (26.7% vs