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At the hormonal level, ketogenesis is strongly regulated by insulin, as it inhibits the breakdown of stored fats in adipocytes and promotes glucose uptake and utilization, leading to elevated levels of inhibitors of fatty acid oxidation and KBs production, such as succinyl-CoA and malonyl-CoA (Johnston and Alberti, 1982)

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HOMA2-IR has an inverse correlation with serum 25(OH) vitamin D levels, and vitamin D supplementation can significantly improve insulin resistance in vitamin D-deficient individuals, particularly when daily doses are used instead of large bolus doses

[DOI] [PubMed] [Google Scholar] 77.Bansal V.K., Rajan K., Sharma A., et al

Therefore, the identification of new drugs for this disease is indispensable

UV/Vis measurement of PLP absorbance One hundred and fifty microliters of PBS containing 1 mM PLP in the absence or presence of the SAAs previously listed was placed in 96-well assay plates and analyzed on a SpectraMax i3 multimode plate reader at an absorbance spectrum between 280 and 460 nm at room temperature