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To preserve cellular homeostasis, organisms have evolved adaptive mechanisms that coordinate nuclear and mitochondrial gene expression

Low concentrations of ascorbate, glutathione, and superoxide dismutase are the most prevalent antioxidant deficits during the pathogenic process of diabetes

The most abundant metabolites in the ATP6AP1 KO cells related to NADH, PPP-associated metabolites such as 6-phosphogluconate and ribose-5-phosphate, whilst glutamine, aspartate and L-cystathionine were decreased, also when treated (Figs

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Research has continued since then, producing promising results