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On one hand, higher expression of PrP might help to satisfy a metabolic demand for extra copper in cells or tissues with elevated Cu consumption 26

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Most patients tolerate it well, which is part of why I am willing to discuss it more freely than peptides with more challenging side effect profiles

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The supernatant fractions enriched with crypts were passed through a 70 m cell strainer and centrifuged at 300 g for 5 min at 4 C

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