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Similarly, increased levels of the DNA oxidation marker 8-hydroxydeoxyguanosine (8-OHdG) were found in endothelial cells [43, 52]

(2022) 20:e3001513

Nebe, V

In contrast to trabectedin, that exhibited dose-dependent cytotoxicity, BBGC treatment at increasing doses (up to the limits of solubility) did not affect cell viability in any of the cell lines, as the half-maximal inhibitory concentration (IC50) was not reached (Fig