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In Asian populations, such as this family of sisters, the HFE mutation is rarely detected, making awareness of FD in patients with features of genetic iron overload important

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Taken together, these results strongly demonstrated the advantages of AEB effect for generating tumor ferroptosis by GPX4 inhibition, thus contributing to a superior tumor control

Interestingly, the identity of the isoleucine PPM transporter, another potential antimalaria drug target due to the parasites requirement to take up isoleucine, is also unknown