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In humans, six months of daily oral administration of genistein has been shown to decrease TNF- levels decreased in obese postmenopausal women (106)

When free radicals damage our cells, the ability of the mitochondria to convert glucose into fuel is hindered leading to a decrease in energy production and metabolism

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ACS omega 8, 2015220162

Diacylglycerol and ceramide accumulation Consistent with the above studies, elevated plasma fatty acid concentrations can result in increased intracellular diacylglycerol (DAG) levels, leading to the activation of protein kinase C isoform (PKC-) and PKC- isoforms in skeletal muscles and liver respectively

Furthermore, through mechanisms such as acidification of the microenvironment, this metabolic shift fosters an immunosuppressive environment favorable for tumor survival, thereby significantly increasing the invasive and metastatic potential of tumor cells [19]