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2 Table 2 Clinical Manifestations of Vitamin B12 Deficiency Maternal vitamin B 12 deficiency during pregnancy or while breastfeeding may lead to neural tube defects, developmental delay, failure to thrive, hypotonia, ataxia, and anemia

Hepatic knockdown of GADD45 enhances hepatic lipogenenic gene expression in MCD diet-fed mice To investigate how GADD45 knockdown aggravates hepatic steatosis, we compared the expression of lipogenesis-related genes in the livers of GADD45-knockdown and control mice fed an MCD diet

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Potential effects on methylation pathways and NAD+ metabolism should be considered

These FAHFAs can be stored as TAGs (156) and mobilized during cold exposure by PNPLA2 to promote de-novo lipogenesis and FA-esterification in an insulin-independent manner (157), possibly explaining the coupling of lipolysis to lipogenesis in adipocytes (151)

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