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In the PTZ model, total iron and Fe 2+ levels increase, with significant upregulation of iron regulatory proteins IRP1, IRP2, and TfR1, along with a decrease in ferroportin 1 (FPN1) and FTH1, and reduced GSH levels accompanied by increased MDA content

) tends to drive monocytes/macrophages toward an M1 state

We demonstrate the importance of this pathway in decreasing inflammatory cytokine release and macrophage pyroptosis in vitro and in vivo

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Mechanisms of increased reactive oxygen species (ROS) generation induced by organic arsenic-lipid (glycerol) derivatives Z10-102