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In this context, recent advances in targeting ROS by administration of glutathione or its precursors (N-acetyl-cysteine, NAC), and also IL-1 signaling by administrating Anakinra, a IL-1 Receptor antagonist (IL-1Ra), have been reported to prevent inflammation and/or worse clinical outcome in COVID-19 patients (102108)

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Therefore, some researchers recommend direct measurement in target tissues or the collection of multiple blood samples at different time points to account for the detoxification effect on circulating levels [66]

10.1016/j.neuropharm.2013.04.024 Neuropharmacology 16 BellantiF.MatteoM.RolloT.De RosarioF.GrecoP.VendemialeG.et al (2013)

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P., Liao, C