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Ceramides, which are elevated in both GWS and ME/CFS, are implicated in the activation of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor (TNF-) within immune cells such as macrophages, as well as in serum (Germain et al., 2020

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GLP-1 activation suppresses appetite and slows gastric emptying, while GIP signaling is thought to enhance energy expenditure, improve insulin sensitivity in adipose tissue, and reduce gastrointestinal side effects through central mechanisms

Combined with the understanding of tumor somatic cell evolution, it can provide a basis for the development of a treatment framework to guide patient immune stratification and immunotherapy decisions

Understanding which component is the best fit for a given technology is one of the most valuable early decisions a company can make