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Animal studies showed fat loss without changing food intake, but it works best combined with healthy eating and activity

The Kraus 2014 study reported that adipocyte-specific NNMT knockdown in mice increased adipocyte energy expenditure through a mechanism interpreted as elevated methyl-donor availability for polyamine biosynthesis and for histone methylation that modulates adipocyte gene-expression programs [2]

Not FDA-approved for weight loss

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The other option is for labs and researchers to buy from "research-use-only" vendors, who provide peptides with no prescription requirement, at a much lower cost

Researchers studying metabolic dysfunction in adipose tissue have identified NNMT as one of the most consistently upregulated enzymes in obese white fat, making it a high-confidence therapeutic target for metabolic intervention