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This mechanism parallels the early packaging events observed in many natural viruses, relying on non-covalent, charge-driven associations to load DNA or RNA either through direct adsorption onto cationic interior surfaces or via cationic polymer bridging strategies, such as the use of polyethyleneimine (PEI) (Cadena-Nava et al., 2012

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This finding suggests that methylmalonic acid and homocysteine levels can be early markers for tissue vitamin B 12 deficiency, even before hematologic manifestations occur

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