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Differences in results are due to a combination of factors including ascorbic acid-related concerns (doses, administration routes, plasmatic levels, metabolites recording, and source), cancer characteristics (specific mutations present, type and grade of cancer, received conventional anti-cancer therapy), and individual characteristics (diet, behaviors, genetics, transporters)

Significantly, an unfavorable EBV DNA response after induction chemotherapy or at the midpoint of RT is also shown to be an adverse prognosticator for clinical outcome

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Figure 5 Contrary to the results obtained after modification in the C-terminal of Ang IV where essentially all compounds examined exhibited some activity, oxidative cyclization of the side chains of Cys 1 and Cys 3 and consequently creation of an 11-membered disulfide macrocycle in the N-terminal rendered the inactive compound 20 (Figure 6)