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Patients with chronic medical conditions may receive IM treatment as part of broader care

10.1371/journal.pone.0068256 PLoS One 396 RicheD

J Immunol 183:62076216

However, post-eradication, new PV vaccines will be required that are not derived from an infectious virus, such as virus-like particle (VLP) vaccines utilising the capacity for recombinantly expressed capsid proteins to self-assemble into empty viral capsids 11

9 reported for the first time in 1990 that the doseresponse curve obtained by acetylcholine in patients with hypertension was smaller than the curve in normal controls and that the doseresponse curves obtained by sodium nitropreside were similar in the two groups, suggesting that endothelial function, but not smooth muscle function, is selectively impaired in patients with hypertension, a large number of studies have shown that hypertension is associated with endothelial dysfunction

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