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Glutathione is an anti-oxidant thats naturally synthesised in our body

In the context of hereditary disorders related to copper metabolism, mutations in the ATP7A and ATP7B genes result in Menkes disease and Wilsons disease, respectively, both of which are marked by impaired transmembrane transport of copper ions, potentially resulting in copper accumulation across various organs [60, 206]

To evaluate whether mutants deficient in different glutathione-dependent enzymes are impacted by TMHT, we subjected cytosolic glutaredoxin mutants to TMHT (Figure 4C)

Even though the main function of the kidney is to excrete waste products from the bloodstream, it is important to mention that the kidney is also a major endocrine organ

The transit of orally administered GSH to tissues is thought to occur via absorption from the intestinal lumen, export from enterocytes into the blood, and uptake from the plasma into cells

Delivery-mediated exosomal therapeutics in ischemia-reperfusion injury: advances, mechanisms, and future directions