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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, et al

Antioxidants: Protect against oxidative stress

CagriSema is not one drug but a fixed combination of two peptides designed to hit appetite and metabolic control through two complementary hormonal pathways at the same time

Burkholder, T., Foltz, C., Karlsson, E., Linton, C

Methods: We designed a new guide selection algorithm, Cas9 3-base & Pam Offset (C3PO), which considers guide pair attributes such as sequence deletion size, cut positions, PAM-orientation, and on/off target efficiency scores to recommend pairs of guides with user-defined deletion and orientation constraints