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Animal models demonstrate its ability to prevent social aversion and alleviate depressive symptoms through diverse mechanisms, including restoring hypothalamic-pituitary-adrenal (HPA) axis function, enhancing brain-derived neurotrophic factor (BDNF) levels, and reducing neuroinflammation and nitric oxide production (Wu et al., 2013

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BDNF has been shown to overcome learning deficits in animal models of AD [63], and reveals increased expression with treadmill exercise [64]

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