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Interestingly, the LIN28B/MYC/miR-34a-5p pathway can be therapeutically exploited: in fact, when using LIN28B inhibitors, miR-34a-5p increases and PKM2 decreases while tumor growth and lung metastasis are suppressed [42]

selenium is a component of the antioxidant enzyme glutathione peroxidase, which helps to fight cell-damaging free-radicals

doi: 10.3390/ijms21176130 41 KlevayL

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Epithalon is administered in defined cycles of ten to twenty days with rest periods between them, responding to pulse-dosing rather than continuous daily administration due to its mechanism of telomere regulation and circadian rhythm modulation