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On EMS arrival, the patient was noted to be obtunded, with a temperature of 31.6C, heart rate of 43 beats/min, blood pressure of 78/45 mm Hg, and respiratory rate of 15 breaths/min

Interestingly, knockdown of HO-1 significantly reduced ACSL4 protein expression in the FAC-treated group compared to the normal FAC-treated group, thereby preventing ACSL4 from catalyzing cellular lipid peroxidation to inhibit ferroptosis, and up-regulated the expression of SLC3A2 and SLC7A11 proteins, while GPX4 protein did not change significantly (Fig

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and Marahel, F., J

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