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This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

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doi:10.1210/jc.2015-3754 PubMed | Crossref | Google Scholar Hurley-Kim K, Vu CH, Dao NM, et al

personal fees for lectures and consultancy fees (paid to his institution) from Boehringer Ingelheim, Eli Lilly, Janssen, Mundipharma, Napp, Sanofi, and Takeda

Enzymes are present in the basal layer of the skin