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The BoxBehnken design (BBD) and response surface modeling (RSM) were employed to determine the ideal conditions for the assay

The combination of DNase-I + amikacin resulted in a strong increase in dead biofilm compared to DNase I treatment alone, and the triple therapy combination of GSH + DNase-I + amikacin showed the highest level of biofilm disruption (Figure 3C)

13: 1220877 (2023) Chien YL, Wu LY, Lee TC, Hwang LS

If stability maintained, healing likely complete

Commenters also stated that the impact of stoploss provisions and prior authorizations are similarly not uniformly distributed and would skew the relative weights