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For example, in the cancer cells, higher temperature can decrease the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) associated with drug resistance 236

In vitro kinase assay and in vitro IC 50 determination The Phosphorylation-Assisted Luciferase Complementation assay (PhALC) was developed to measure JNK activity in vitro for fast and cost-effective identification/characterization of any compound blocking MAPK activity 35

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