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For individuals with moderate kidney impairment (creatinine clearance 3050 mL/min), the dose is reduced to 333 mg three times daily

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Gabrielle Lyon, DO Board-Certified Family Physician Founder, Institute for Muscle-Centric Medicine Author, Forever Strong Source: Integrative & Complementary Therapies, 2024 InsideTracker Longevity by Design Podcast, 2025 A 2025 joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society emphasized that nutritional counseling is essential for patients on GLP-1 therapy not optional

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Research has also suggested that vitamin B12 is critical in synthesizing neurotransmitters such as dopamine and serotonin, which are involved in mood regulation and cognitive function