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While the inhibitory potency is limited and unlikely to be pharmacologically relevant at physiological concentrations, the combined in vitro and in silico findings offer valuable mechanistic and structural insight into auxinGSTP1-1 interactions

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Giles FJ, Miller CB, Hurd DD, Wingard JR, Fleming TR, Sonis ST, Bradford WZ, Pulliam JG, Anaissie EJ, Beveridge RA, Brunvand MM, Martin PJ, PROMPT-CT Trial Investigators: A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT trial)

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Cats with CKD fall into four stages progressively advancing to the final stage, Stage 4 (where cats can live a maximum of 35 days): Source: Northern Suburbs Veterinary Hospital In the final stage, Stage 4, the symptoms to look for include: Refusal to eat or drink, an inability to walk, continued weight loss, vomiting, incontinence, confusion, hiding, restlessness, seizures, and/or shortness of breath