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Minott JA, van Vloten JP, Yates JGE, Chan L, Wood GA, Viloria-Petit AM, et al

The human lung adenocarcinoma cell line A549 was purchased from Shanghai Institute of Cellular Biology of Chinese Academy of Sciences (Shanghai, China)

Lancet 1993

CD4 is an interesting molecule from the point of view of evolution of thiol-based redox signaling

It is postulated herein that the detrimental activation of autoimmune T cells by glutamate in MS could lead to: (1) Cytotoxicity in the CNS: T cell-mediated killing of neurons and glia cells, which would subsequently increase the extracellular glutamate levels, and by doing so increase the excitotoxicity mediated by excess glutamate, (2) Release of proinflammatory cytokines, e.g., TNF and IFN that increase neuroinflammation

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