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For example, GPER promotes the phosphorylation of AMPK, enhancing cellular adaptation to energy deficits and improving metabolic efficiency [170, 221, 222]

Other additions to Category 1 include ruxolitinib phosphate, a JAK1and JAK2 inhibitor currently commercially available orally and topically for conditions such as myelofibrosis or atopic dermatitis respectively and dimercaprol,a chelating drug currently commercially-available as an injectable

424 However, the widespread adoption of AI-driven platforms such as the EyeArt system raises critical ethical concerns, particularly regarding data privacy and security