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Metabolic reprogramming is important for macrophage survival, where the classically activated (M1) macrophages rely predominantly on glycolysis to maintain their pro-inflammatory nature, while the alternatively activated (M2) macrophages use oxidative phosphorylation and fatty acid oxidation to fulfil their reparative activities

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A series of recent compelling evidence has suggested that mitochondria play a key role in ferroptosis (7)

Lancet (Lond., Engl.) 389 , 5666 (2017)