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Considering that current anti-inflammatory therapy (steroids and immunosuppressant drugs) remains unsatisfactory due to substantial side effects and uncontrolled relapses (349), understand the interaction between gut microbiota and IEB, particularly at the early subclinical phase of inflammatory disease, could be used to identify novel therapeutic approaches in chronic intestinal inflammation

The cellular level concentration of GSH is maintained by glutathione reductase (GR) [39], which reduces GSSG to GSH by using NADPH as cofactor

Lindsten, T, Ross, AJ, Gottlieb-King, A, Zong, W-X, Rathmell, JC, Shiels, HA, Ulrich, E, Waymire, KG, Mahar, PL, Frauwirth, K, Chen, Y, Wei, M, Eng, VM, Adelman, DM, Simon, MC, Ma, A, Golden, JA, Evan, G Korsmeyer, SJ, MacGregor, GR and Thompson, CB (2000) The combined functions of the pro-apoptotic BCL2 family members BAK and BAX are essential for the normal development of multiple tissues

Furthermore, the involvement of CHAC1 in non-malignant diseases, such as diabetes, liver injury, and respiratory disorders, adds complexity, as its therapeutic modulation could potentially worsen these conditions by disrupting GSHmetabolism and increasing oxidative stress

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doi: 10.1038/s41579-018-0019-y 9 ArerV.KarD