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Customized porous structures in scaffolds by 3D printing technology can overcome the limitations of hydrogel particles in multiscale delivery systems

Additional studies have shown that spinal fusion may result in degeneration of adjacent discs and lead to further discogenic pain, herniation, stenosis or spondylosis, suggesting that improvements in surgical interventions for back pain are necessary (Ghiselli et al., 2004)

The 1:2,500 ratio, however, shows superior efficacy, outperforming the alternatives up to the highest dose

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The differentiation of hepatocytes within distinct zones of the liver lobules maybe a result of the interplay of four key factors: the physiological direction of blood flow, the mutual exclusivity of functional roles, differential gene expression, and the influence of the local microenvironment

In addition to its potentials on activating cellular antioxidant defense system, black cumin can directly scavenge free radicals, as demonstrated in several in vitro chemical assays like DPPH assay [35,292,293,294]