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In addition, fumaric acid may affect the catabolism of tyrosine and inhibit the enzyme activity therein, which ultimately leads to an elevation of tyrosine and so on in biochemical tests [85]

Metabolism 54(3):345350

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The authors of this comprehensive study concluded that excess sugar intake resulted in increased de novo lipogenesis, which led to a suppression of hepatic HNF-4 activity, which in turn attenuated sex hormone-binding globulin expression