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Characterized by lipid peroxidation and abnormal iron accumulation, ferroptosis has attracted significant attention due to its unique association with pathological conditions such as ischemia-reperfusion injury, neurodegeneration, and cancer [2,3,4]

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162,163,164 There is evidence that ROS engages in inflammasome activation in multiple tissues

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5.1.1 M1 macrophages Upon encountering allergens or pollutants, macrophages often polarize toward a pro-inflammatory M1 phenotype

Sulfotransferases Sulfortranferasese are cytosolic conjugating metabolizing enzymes which use '-phosphoadenosine 5'-phosphosulfate (PAPS) as the donor of sulfate groups and transfer them to an acceptor substrate compounds