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Myosin II contains a myosin light chain, and ROCK phosphorylates this chain [90]

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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress

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Importantly, TNF- synergizes with IFN- to downregulate phosphoenolpyruvate carboxykinase 1 (PCK1) expression [72]

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