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On the other hand, IL-1 can feedback-stimulate NADPH oxidase, further exacerbating oxidative stress ( 3.2 Oxidative stress and metabolic dysregulation Mitochondrial dysfunction mediated by the SIRT1/NAD + pathway represents a pivotal mechanism in DN pathogenesis, where oxidative stress emerges as a central driver

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Zhang Y, Huang X, Liu N, Liu M, Sun C, Qi B, et al