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evidence for phosphorus, magnesium, iodine, and molybdenum remains conflicting or limited

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Pfizer's danuglipron, once considered the primary competitor, was discontinued in April 2025 after a case of potential drug-induced liver injury in a dose-optimization study, following the earlier termination of lotiglipron in 2023 for similar hepatic concerns

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To address this, we used updated voxelwise methods and retrospectively analyzed a [ 11 C]raclopride-PET dataset to measure D 2/3 receptor availability and relative cerebral blood flow (R1) in male opioid use disorder (OUD) participants ( n = 10) during placebo and acute opioid withdrawal conditions

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