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Interestingly, there is emerging evidence that TCAs may improve liver fibrosis and reduce portal hypertensive complications, a potential dual benefit that warrants further investigation [55, 56]

At the genetic level, two common functional polymorphisms, C677T (rs1801133) and A1298C (rs1801131), are widely studied for their effects on enzyme thermolability and folate/homocysteine status

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Suppression of tumor growth by senescence in virally transformed human fibroblasts

More importantly, by restoring mitochondrial integrity via overexpressing hHsp27, the development of mechanical and cold allodynia was completely prevented in paclitaxel-treated or vincristine-treated hHsp27 overexpressing mice (Chine et al., 2019a,b)

Computational screening of natural MtbDXR inhibitors for novel anti-tuberculosis compound discovery