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Inflammatory factors and oxidative stress damage the intestinal mucosal barrier, leading to reduced expression and impaired function of tight junction proteins, as well as increased intestinal permeability

Sci Rep 3:1199

Thus, UA promotes autophagic cell death and triggers ferroptosis, establishing it as a promising therapeutic agent in cancer treatment

Hoboken, NJ: Wiley, pp

In response, plants activate nutrient transporters (ZIP, NRAMP, HKT, PHT), synthesize chelators (phytosiderophores), and exude organic acids to improve nutrient acquisition and redistribution