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Oral bioavailability of total NAC was 9.1%

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In preclinical studies published in Endocrinology, researchers found that chronic administration of AOD-9604 reduced body weight and body fat in obese mice while increasing beta-3 adrenergic receptor expression to levels comparable with lean mice

On the contrary, a study elucidating the primary adverse effects associated with NAC treatment shows NAC treatment predominantly manifests as mild gastrointestinal symptoms (Dodd et al., 2008)

Normal gut microbiota-derived SCFAs stimulate glucagon-like peptide-1 secretion, which exerts protective effects against renal oxidative stress and chronic hyperglycemia

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