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Moreover, LFB staining results showed myelin loss in the lesion without iron deposition, as confirmed by PB staining

The mechanism of this neurologic deterioration is not fully understood, but appears to be related to dosage since a high starting dose could increase the risk of rapid chelator-induced paradoxical worsening

How should researchers compare variants

The abdomen (avoiding a 2-inch radius around the navel), outer thigh, and upper arm provide suitable injection locations with adequate subcutaneous tissue