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Additionally, pinocembrin has been shown to restore cognitive function and reduce neuronal apoptosis and hippocampal inflammation in vivo, mainly by inhibiting NLRP3 inflammasome formation, reducing microglial infiltration, and enhancing BNIP3-mediated mitophagy through the JNK-ERK signaling pathway [175]

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This therapy has been approved by the FDA and holds the potential to relieve both inflammation and pain symptoms

Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit