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and/or, (vi) an ADC with such variant anti-FRa antibody provides similar or higher in vivo efficacy in tumor-bearing mouse xenograft models as the corresponding control ADC with mAb1 as the anti-FRa antibody, for example using one of the xenograft models as used in the Examples

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Many of these studies, either due to the small patient sample size, with uncontrolled admissions and treatment criteria, or due to relevant bias of the clinical studies failed to give precise information on effectiveness and practical advantage in taking antioxidants