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Within the synaptic cleft, Glu levels are mainly regulated by the Glu/Gln shuttle clearing extracellular Glu through different sodium-dependent glial Glu transporters (EAAT1 and 2) and the cystine/glutamate exchanger [68]

PMC 5560858

Indeed, 6-OHDA induced nigral-striatal brain lesions caused a reduction in fecal output 39 , further asserting a relationship between the gut and brain