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Compr Physiol 4:177197

The therapeutic landscape for diabetic complications has been reshaped by agents with proven cardiorenal benefits, including sodiumglucose cotransporter 2 inhibitors, glucagonlike peptide-1 receptor agonists, and nonsteroidal mineralocorticoid receptor antagonists, with combination therapies offering potential additive or synergistic effects

This mechanistic advantage reflects tirzepatide's broader impact on multiple metabolic control centers, offering context for why some patients experience more robust appetite suppression